Shimamoto S, Nishimura Y, Nagamatsu G, Hamada N, Kita H, Hikabe O, Hamazaki N, Hayashi K.

Hypoxia induces the dormant state in oocytes through expression of Foxo3.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12321-12326. doi: 10.1073/pnas.1817223116. Epub 2019 May 30.PubMed

Nagamatsu G, Shimamoto S, Hamazaki N, Nishimura Y, Hayashi K.

Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes.

Sci Adv. 2019 Jun 26;5(6):eaav9960. doi: 10.1126/sciadv.aav9960. eCollection 2019 Jun.PubMed

Octavera A, Yoshizaki G.

Production of donor-derived offspring by allogeneic transplantation of spermatogonia in Chinese rosy bitterling.

Biol Reprod. 2019 Apr 1;100(4):1108-1117. doi: 10.1093/biolre/ioy236.PubMed

Ichida K, Kawamura W, Miwa M, Iwasaki Y, Kubokawa T, Hayashi M, Yazawa R, Yoshizaki G.

Specific visualization of live type A spermatogonia of Pacific bluefin tuna using fluorescent dye-conjugated antibodies.

Biol Reprod. 2019 Jun 1;100(6):1637-1647. doi: 10.1093/biolre/ioz047.PubMed

Duangkaew R, Jangprai A, Ichida K, Yoshizaki G, Boonanuntanasarn S.

Characterization and expression of a vasa homolog in the gonads and primordial germ cells of the striped catfish (Pangasianodon hypophthalmus).

Theriogenology. 2019 Jun;131:61-71. doi: 10.1016/j.theriogenology.2019.01.022. Epub 2019 Mar 15.PubMed

Hayashi M, Ichida K, Sadaie S, Miwa M, Fujihara R, Nagasaka Y, Yoshizaki G.

Establishment of novel monoclonal antibodies for identification of type A spermatogonia in teleosts.

Biol Reprod. 2019 May 11. pii: ioz080. doi: 10.1093/biolre/ioz080. [Epub ahead of print] PMID: 31077286PubMed

Sasaki K, Hara S, Yamakami R, Sato Y, Hasegawa S, Kono T, Morohaku K, Obata Y.

Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice.

Mol Reprod Dev. 2019 Jun;86(6):614-623. doi: 10.1002/mrd.23137. Epub 2019 Mar 4.PubMed

Marinovic Z, Li Q, Lujic J, Iwasaki Y, Csenki Z, Urbanyi B, Yoshizaki G, Horvath A.

Preservation of zebrafish genetic resources through testis cryopreservation and spermatogonia transplantation.

Sci Rep. 2019; 9: 13861. doi: 10.1038/s41598-019-50169-1.PubMed

Kobayashi T*, Kobayashi H*, Goto T, Takashima T, Oikawa M, Ikeda H, Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K, Hirabayashi M.(*equal contribution)

Germline development in rat revealed by visualization and deletion of Prdm14.

Development. 2020 Jan 30. pii: dev.183798. doi: 10.1242/dev.183798.PubMed

Kei-ichiro Ishiguro, Kumi Matsuura, Naoki Tani, Naoki Takeda, Shingo Usuki, Mariko Yamane, Michihiko Sugimoto, Sayoko Fujimura, Mihoko Hosokawa, Shinichiro Chuma, Minoru S.H. Ko, Kimi Araki and Hitoshi Niwa

MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells

Developmental Cell 52(4) doi: 10.1016/j.devcel.2020.01.010. [Epub ahead of print]PubMed

M. Kutsukake, M. Moriyama, S. Shigenobu, X-Y Meng, N. Nikoh, C. Noda, S. Kobayashi and T. Fukatsu

Exaggeration and co-option of innate immunity for social defence.

Proc. Natl. Acad. Sci. USA.2019 Apr 30;116(18):8950-8959. doi: 10.1073/pnas.1900917116. Epub 2019 Apr 15.PubMed

M. Asaoka, K. Hanyu-Nakamura, A. Nakamura and S. Kobayashi

Maternal Nanos inhibits Importin-a2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.

PLoS Genetics. 2019 May; 15(5): e1008090. doi: 10.1371/journal.pgen.1008090PubMed

S. Nakamura, S. Hira, M. Fujiwara, N. Miyagata, T. Tsuji, A. Kondo, H. Kimura, Y. Shinozuka, M. Hayashi, S. Kobayashi, M. Mukai

A truncated form of a transcription factor Mamo activates vasa in Drosophila embryos.

Commun Biol. 2019 Nov 20;2:422. doi: 10.1038/s42003-019-0663-4. eCollection 2019.PubMed

S. Morita, R. Ota, M. Hayashi and S. Kobayashi

Repression of G1/S transition by transient inhibition of miR-10404 expression in Drosophila primordial germ cells.

iScience. 2020 Feb 28;23(3):100950. doi: 10.1016/j.isci.2020.100950 [Epub ahead of print]PubMed

Hamada N, Hamazaki N, Shimamoto S, Hikabe O, Nagamatsu G, Takada Y, Kato K, Hayashi K.

Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice.

PLoS Genet. 2020 Mar 26;16(3):e1008676. doi: 10.1371/journal.pgen.1008676. eCollection 2020 Mar.PubMed

Terada M, Kawamata M, Kimura R, Sekiya S, Nagamatsu G, Hayashi K, Horisawa K, Suzuki A.

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells.

Genesis. 2019 Nov;57(11-12):e23334. doi: 10.1002/dvg.23334. Epub 2019 Sep 12.PubMed

Nagaoka SI, Nakaki F, Miyauchi H, Nosaka Y, Ohta H, Yabuta Y, Kurimoto K, Hayashi K, Nakamura T, Yamamoto T, Saitou M.

ZGLP1 is a determinant for the oogenic fate in mice.

Science. 2020 Mar 6;367(6482). pii: eaaw4115. doi: 10.1126/science.aaw4115. Epub 2020 Feb 13.PubMed

Anna Kouznetsova, Tomoya S Kitajima, Hjalmar Brismar, Christer Hoog

Post‐metaphase correction of aberrant kinetochore‐microtubule attachments in mammalian eggs

EMBO Rep. 2019 Aug; 20(8): e47905. Published online 2019 Jul 10. doi: 10.15252/embr.201947905PubMed

Mitsuru Komeya, Hiroyuki Yamanaka, Hiroyuki Sanjo, Masahiro Yao, Hiroko Nakamura, Hiroshi Kimura, Teruo Fujii, Takuya Sato, Takehiko Ogawa

In vitro spermatogenesis in two‐dimensionally spread mouse testis tissues

Reprod Med Biol. 2019 Oct; 18(4): 362-369. Published online 2019 Aug 13. doi: 10.1002/rmb2.12291PubMed

Seiki Haraguchi, Mitsumi Ikeda, Satoshi Akagi, Yuji Hirao

Dynamic Changes in pStat3 Are Involved in Meiotic Spindle Assembly in Mouse Oocytes

Int J Mol Sci. 2020 Feb; 21(4): 1220. Published online 2020 Feb 12. doi: 10.3390/ijms21041220PubMed

Hisanori Fukunaga, Kiichi Kaminaga, Takuya Sato, Karl T. Butterworth, Ritsuko Watanabe, Noriko Usami, Takehiko Ogawa, Akinari Yokoya, Kevin M. Prise

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Sci Rep. 2019; 9: 12618. Published online 2019 Oct 1. doi: 10.1038/s41598-019-48772-3PubMed

Kosuke Hashimoto, Tsukasa Kouno, Tomokatsu Ikawa, Norihito Hayatsu, Yurina Miyajima, Haruka Yabukami, Tommy Terooatea, Takashi Sasaki, Takahiro Suzuki, Matthew Valentine, Giovanni Pascarella, Yasushi Okazaki, Harukazu Suzuki, Jay W. Shin, Aki Minoda, Ichi

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Proc Natl Acad Sci U S A. 2019 Nov 26; 116(48): 24242-24251. Published online 2019 Nov 12. doi: 10.1073/pnas.1907883116PubMed

Yutaka Yawata, Tatsunori Kiyokawa, Yuhki Kawamura, Tomohiro Hirayama, Kyosuke Takabe, Nobuhiko Nomura

Intra- and Interspecies Variability of Single-Cell Innate Fluorescence Signature of Microbial Cell

Appl Environ Microbiol. 2019 Sep 15; 85(18): e00608-19. Prepublished online 2019 Jul 19. Published online 2019 Aug 29. doi: 10.1128/AEM.00608-19PubMed

Douglas R. Brumley, Francesco Carrara, Andrew M. Hein, Yutaka Yawata, Simon A. Levin, Roman Stocker

Bacteria push the limits of chemotactic precision to navigate dynamic chemical gradients

Proc Natl Acad Sci U S A. 2019 May 28; 116(22): 10792-10797. Published online 2019 May 16. doi: 10.1073/pnas.1816621116PubMed

Mizuho Kanamori, Kenta Oikawa, Kentaro Tanemura, Kenshiro Hara

Mammalian germ cell migration during development, growth, and homeostasis

Reprod Med Biol. 2019 Jul; 18(3): 247-255. Published online 2019 Jun 9. doi: 10.1002/rmb2.12283PubMed

Shouhei KURATA, Yuuki HIRADATE, Kohei UMEZU, Kenshiro HARA, Kentaro TANEMURA

Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration

J Reprod Dev. 2019 Aug; 65(4): 327-334. Published online 2019 Jun 10. doi: 10.1262/jrd.2019-008PubMed

Kohei UMEZU, Risa YAJIMA, Yuuki HIRADATE, Rin YANAI, Takashi NUMABE, Kenshiro HARA, Toshinori OIKAWA, Kentaro TANEMURA

Improvement in blastocyst quality by neurotensin signaling via its receptors in bovine spermatozoa during in vitro fertilization

J Reprod Dev. 2019 Apr; 65(2): 147-153. Published online 2019 Jan 19. doi: 10.1262/jrd.2018-147PubMed

Mohamed Osama Ali Abdalla, Tatsuro Yamamoto, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hisashi Miura, Rawin Poonperm, Ichiro Hiratani, Hideki Nakayama, Mitsuyoshi Nakao, Noriko Saitoh

The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Nat Commun. 2019; 10: 3778. Published online 2019 Aug 22. doi: 10.1038/s41467-019-11378-4PubMed

Shoko Sato, Yasuhiro Arimura, Tomoya Kujirai, Akihito Harada, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hitoshi Kurumizaka

Biochemical analysis of nucleosome targeting by Tn5 transposase

Open Biol. 2019 Aug; 9(8): 190116. Published online 2019 Aug 14. doi: 10.1098/rsob.190116PubMed

Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Takamasa Masuda, Nobuyuki Shimizu, Yasuyuki Ohkawa, Tohru Ishitani

Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo

Nat Commun. 2019; 10: 4710. Published online 2019 Oct 17. doi: 10.1038/s41467-019-12609-4PubMed

Hanna Witwicka, Jumpei Nogami, Sabriya A. Syed, Kazumitsu Maehara, Teresita Padilla-Benavides, Yasuyuki Ohkawa, Anthony N. Imbalzano

Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme

Mol Cell Biol. 2019 Oct 1; 39(19): e00063-19. Published online 2019 Sep 11. Prepublished online 2019 Jul 15. doi: 10.1128/MCB.00063-19PubMed

Mayo Araki, Massanori Kurihara, Suzuko Kinoshita, Rie Awane, Tetsuya Sato, Yasuyuki Ohkawa, Yoshihiro H. Inoue

Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants

Dis Model Mech. 2019 Jun 1; 12(6): dmm037721. Published online 2019 Jun 18. doi: 10.1242/dmm.037721PubMed

Masami Miki, Takamasa Oono, Nao Fujimori, Takehiro Takaoka, Ken Kawabe, Yoshihiro Miyasaka, Takao Ohtsuka, Daisuke Saito, Masafumi Nakamura, Yasuyuki Ohkawa, Yoshinao Oda, Mikita Suyama, Tetsuhide Ito, Yoshihiro Ogawa

CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors

Cancer Med. 2019 Jul; 8(8): 3748-3760. Published online 2019 May 25. doi: 10.1002/cam4.2232PubMed

Kazu Kobayakawa, Yasuyuki Ohkawa, Shingo Yoshizaki, Tetsuya Tamaru, Takeyuki Saito, Ken Kijima, Kazuya Yokota, Masamitsu Hara, Kensuke Kubota, Yoshihiro Matsumoto, Katsumi Harimaya, Keiko Ozato, Takahiro Masuda, Makoto Tsuda, Tomohiko Tamura, Kazuhide Ino

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Sci Adv. 2019 May; 5(5): eaav5086. Published online 2019 May 15. doi: 10.1126/sciadv.aav5086PubMed

Takashi Kozuka, Yoshihiro Omori, Satoshi Watanabe, Etsuko Tarusawa, Haruka Yamamoto, Taro Chaya, Mayu Furuhashi, Makiko Morita, Tetsuya Sato, Shinichi Hirose, Yasuyuki Ohkawa, Yumiko Yoshimura, Takatoshi Hikida, Takahisa Furukawa

miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation

Sci Rep. 2019; 9: 3445. Published online 2019 Mar 5. doi: 10.1038/s41598-019-38910-2PubMed

Kiyono Sekii, Shunta Yorimoto, Hikaru Okamoto, Nanna Nagao, Takanobu Maezawa, Yasuhisa Matsui, Katsushi Yamaguchi, Ryohei Furukawa, Shuji Shigenobu, Kazuya Kobayashi

Transcriptomic analysis reveals differences in the regulation of amino acid metabolism in asexual and sexual planarians

Sci Rep. 2019; 9: 6132. Published online 2019 Apr 16. doi: 10.1038/s41598-019-42025-zPubMed

Rie Saba, Keiko Kitajima, Lucille Rainbow, Silvia Engert, Mami Uemura, Hidekazu Ishida, Ioannis Kokkinopoulos, Yasunori Shintani, Shigeru Miyagawa, Yoshiakira Kanai, Masami Kanai-Azuma, Peter Koopman, Chikara Meno, John Kenny, Heiko Lickert, Yumiko Saga,

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice

Sci Rep. 2019; 9: 11953. Published online 2019 Aug 16. doi: 10.1038/s41598-019-48321-yPubMed

Kento Miura, Kyoko Harikae, Mayu Nakaguchi, Kenya Imaimatsu, Ryuji Hiramatsu, Ayako Tomita, Yoshikazu Hirate, Masami Kanai-Azuma, Masamichi Kurohmaru, Atsuo Ogura, Yoshiakira Kanai

Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice

PLoS One. 2019; 14(3): e0212367. Published online 2019 Mar 6. doi: 10.1371/journal.pone.0212367PubMed

Manabu Bessho-Uehara, Naoyuki Yamamoto, Shuji Shigenobu, Hitoshi Mori, Keiko Kuwata, Yuichi Oba

Kleptoprotein bioluminescence: Parapriacanthus fish obtain luciferase from ostracod prey

Sci Adv. 2020 Jan; 6(2): eaax4942. Published online 2020 Jan 8. doi: 10.1126/sciadv.aax4942PubMed

Shino Goto-Yamada, Kazusato Oikawa, Jakub Bizan, Shuji Shigenobu, Katsushi Yamaguchi, Shoji Mano, Makoto Hayashi, Haruko Ueda, Ikuko Hara-Nishimura, Mikio Nishimura, Kenji Yamada

Sucrose Starvation Induces Microautophagy in Plant Root Cells

Front Plant Sci. 2019; 10: 1604. Published online 2019 Dec 3. doi: 10.3389/fpls.2019.01604PubMed

Yuu Ishii, Shinichiro Maruyama, Hiroki Takahashi, Yusuke Aihara, Takeshi Yamaguchi, Katsushi Yamaguchi, Shuji Shigenobu, Masakado Kawata, Naoto Ueno, Jun Minagawa

Global Shifts in Gene Expression Profiles Accompanied with Environmental Changes in Cnidarian-Dinoflagellate Endosymbiosis

G3 (Bethesda) 2019 Jul; 9(7): 2337-2347. Published online 2019 May 16. doi: 10.1534/g3.118.201012PubMed

Satoshi Yamashita, Kensuke Kataoka, Hiroto Yamamoto, Tomoko Kato, Satoshi Hara, Katsushi Yamaguchi, Claire Renard-Guillet, Yuki Katou, Katsuhiko Shirahige, Haruki Ochi, Hajime Ogino, Tokujiro Uchida, Masafumi Inui, Shuji Takada, Shuji Shigenobu, Hiroshi A

Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken

Sci Rep. 2019; 9: 12560. Published online 2019 Aug 29. doi: 10.1038/s41598-019-48979-4PubMed

Tomoyuki Shikata, Fumio Takahashi, Hiroyo Nishide, Shuji Shigenobu, Yasuhiro Kamei, Setsuko Sakamoto, Kouki Yuasa, Yoshitaka Nishiyama, Yasuhiro Yamasaki, Ikuo Uchiyama

RNA-Seq Analysis Reveals Genes Related to Photoreception, Nutrient Uptake, and Toxicity in a Noxious Red-Tide Raphidophyte Chattonella antiqua

Front Microbiol. 2019; 10: 1764. Published online 2019 Jul 31. doi: 10.3389/fmicb.2019.01764PubMed

Masatoshi Matsunami, Miyuki Suzuki, Yoshikazu Haramoto, Akimasa Fukui, Takeshi Inoue, Katsushi Yamaguchi, Ikuo Uchiyama, Kazuki Mori, Kosuke Tashiro, Yuzuru Ito, Takashi Takeuchi, Ken-ichi T Suzuki, Kiyokazu Agata, Shuji Shigenobu, Toshinori Hayashi

A comprehensive reference transcriptome resource for the Iberian ribbed newt Pleurodeles waltl, an emerging model for developmental and regeneration biology

DNA Res. 2019 Jun; 26(3): 217-229. Published online 2019 Apr 22. doi: 10.1093/dnares/dsz003PubMed

Nahoko Uchi, Mitsutaka Fukudome, Narumi Nozaki, Miyuzu Suzuki, Ken-ichi Osuki, Shuji Shigenobu, Toshiki Uchiumi

Antimicrobial Activities of Cysteine-rich Peptides Specific to Bacteriocytes of the Pea Aphid Acyrthosiphon pisum

Microbes Environ. 2019 Jun; 34(2): 155-160. Published online 2019 Mar 21. doi: 10.1264/jsme2.ME18148PubMed

Yoshiki Hayashi, Yuto Yoshinari, Satoru Kobayashi and Ryusuke Niwa

The regulation of Drosophila ovarian stem cell niches by signaling crosstalk

Curr Opin Insect Sci. 2020 Jan 30;37:23-29. doi: 10.1016/j.cois.2019.10.006.PubMed

Kanako MOROHAKU

A way for in vitro/ex vivo egg production in mammals

J Reprod Dev. 2019 Aug; 65(4): 281-287. Published online 2019 Apr 20. doi: 10.1262/jrd.2019-024PubMed

Hayashi K

In Vitro Reconstitution of Germ Cell Development.

Biol Reprod. 2019 Jul 11. pii: ioz111. doi: 10.1093/biolre/ioz111.PubMed

Masato Sorida, Takahiro Hirauchi, Hiroaki Ishizaki, Wataru Kaito, Atsushi Shimada, Chie Mori, Yuji Chikashige, Yasushi Hiraoka, Yutaka Suzuki, Yasuyuki Ohkawa, Hiroaki Kato, Shinya Takahata, Yota Murakami

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1

PLoS Genet. 2019 Jun; 15(6): e1008129. Published online 2019 Jun 17. doi: 10.1371/journal.pgen.1008129PubMed

Kanamori M, Oikawa K, Tanemura K, Hara K.

Mammalian germ cell migration during development, growth, and homeostasis.

Reprod Med Biol. 2019 Jun 9;18(3):247-255. doi: 10.1002/rmb2.12283.PubMed

Kurimoto K, Saitou M.

Germ cell reprogramming.

Curr Top Dev Biol. 2019;135:91-125. doi: 10.1016/bs.ctdb.2019.04.005. Epub 2019 May 9.PubMed

Yoshizaki G, Yazawa R.

Application of surrogate broodstock technology in aquaculture.

Fish Sci. 2019 May; 85(3): 429-437. doi: 10.1007/s12562-019-01299-y.

Shinichi Morita, Toshiya Ando, Akiteru Maeno, Takeshi Mizutani, Mutsuki Mase, Shuji Shigenobu, Teruyuki Niimi

Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental contexts

PLoS Genet. 2019 Apr; 15(4): e1008063. Published online 2019 Apr 10. doi: 10.1371/journal.pgen.1008063PubMed

Shosei Yoshida

Mouse Spermatogenesis Reflects the Unity and Diversity of Tissue Stem Cell Niche Systems

Cold Spring Harb Perspect Biol. 2020 Dec 1;12(12):a036186. doi: 10.1101/cshperspect.a036186.PubMed

Yoshida S

Heterogeneous, dynamic, and stochastic nature of mammalian spermatogenic stem cells.

Curr Top Dev Biol, 2019, 135, 245-285, doi: 10.1016/bs.ctdb.2019.04.008PubMed